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Turkish Journal of Fisheries and Aquatic Sciences 2019, Vol 19, Num, 10     (Pages: 847-855)

Pharmacokinetics and Tissue Residues of Minocycline in Carp (Cyprinus carpio) after Oral Administration

Zaijian Li 1 ,Wenqiang Liu 1 ,Yubao Li 1 ,Xuling Qin 1 ,Cuilan Chen 2 ,Jiyue Cao 2

1 Liaocheng University, College of Agriculture, Shandong Liaocheng, 252000China
2 Huazhong Agricultural University, College of Veterinary Medicine, Wuhan, 430070 China
DOI : 10.4194/1303-2712-v19_10_04 Viewed : 2874 - Downloaded : 2141 The pharmacokinetics and residues elimination of Minocycline(MINO) were studied in healthy carp (Cyprinus carpio,400±30 g) kept at water temperatures of 10 and 25°C. The concentrations of MINO in plasma and tissues were determined using highperformance liquid chromatography (HPLC) using an ultraviolet detector. The plasma concentrations of MINO concentration-time data were fitted using a singlecompartment model at 10 and 25°C. The absorption half-life (t1/2ka) of MINO was 2.65 h at 10°C and 1.65 hat 25°C, whereas the elimination half-life (t1/2ke) was 11.16 h at 10 °C and 16.343.78 h at 25°C; the maximum plasma concentration (Cmax) and the time-point of maximum plasma concentration (Tp) were calculated as 2.34 µg mL-1 and 7.21 h at 10°C, 2.97 µg mL-1 and 3.50 h at 25°C. The distribution volume (Vd/F) of MINO was estimated to be 4.09 L kg-1 at 10 °C and 2.66 L kg-1 at 25 °C; the total body clearance (CLb) of MINO were computed as 0.25 and 0.49 L/ (h·kg) at 10 and 25°C, respectively; the areas under the concentration-time curve (AUC) was 59.07 µg mL-1h at 10°C and 30.72 µg mL-1h at 25°C. The concentrations of MINO were detected in muscle, skin, liver and kidney. The MINO could still be detected at 5 d time-point after administration at both temperatures in all tissues. The results revealed that the depletion of MINO in carp was slower with a long half-life time, especially at lower water temperature. If fish were administered MINO orally with a single dose (10 mg/kg·bw) for several days, the withdrawal periods of MINO could be not less than 19 d at winter water temperature (10℃) and 8 d at summer water temperature (25℃). Keywords : Antimicrobial, Pharmacokinetics, Residues, Maximum residue limit