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Turkish Journal of Fisheries and Aquatic Sciences 2019, Vol 19, Num, 8     (Pages: 653-659)

Isolation and Bioactivities Screening of Turkish Microcosmus vulgaris

Belma Konuklugil 1 ,Melek Sertdemir 2 ,Hajar Heydari 1 ,Aslı Koc 3

1 Ankara University, Faculty of Pharmacy, Pharmacognosy Department, Ankara, Turkey
2 Ankara University, Biotechnology Institute, Basic Biotechnology, Ankara, Turkey
3 Ankara University, Faculty of Pharmacy, Biochemistry Department, Ankara, Turkey
DOI : 10.4194/1303-2712-v19_8_03 Viewed : 2687 - Downloaded : 2393 During the course of our investigation for isolation of biological active compounds from marine organisms of the Turkish seas, secondary metabolites and bioactivities of, Microcosmus vulgaris collected from (Turkish coasts) İzmir coast was studied. In the study 5α- 6α- epoxyergosta 7-en- 3β- ol was isolated from Microcosmus vulgaris. Furthermore, antioxidant and antiproliferative activity of crude extract and 5α- 6α- epoxyergosta 7-en- 3β- ol were determined by DPPH, superoxide radical scavenging and nitric oxide radical scavenging and MTT assay respectively. Antimicrobial activity of crude extract was also determined against some Gram positive, Gram negative and yeast strains. Stearic acid, palmitic acid and myristic acid were also detected by GCMASS analysis. This is the first study about isolation and bioactivity determination of Turkish M. vulgaris. Keywords : Bioactivity, Marine natural products, Microcosmus vulgaris, Tunicate