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Turkish Journal of Fisheries and Aquatic Sciences 2011, Vol 11, Num, 3     (Pages: 339-344)

Arsenic Impairs the Effect of Low Temperature on the Regulation of Na+- K+ ATPase Activity in Skeletal Muscle of Fish (Channa punctata)

Md. Shahidul Haque 1 ,Swapan Kumar Roy 1 ,M. Shahjahan 1

1 University of Rajshahi, Department of Biochemistry and Molecular Biology, Rajshahi-6205, Bangladesh DOI : 10.4194/1303-2712-v11_3_01 Viewed : 1981 - Downloaded : 1297 To characterize whether environmental low temperature is involved in metabolic regulation, Channa punctata species of fish were exposed to cold (4~8°C) for 30 min, 1 hr and 2 hrs since they are much energetic and survive in the critical environment. The inorganic phosphate (Pi) in skeletal muscle was significantly increased after 1 hr in cold compared to control fish kept in ambient temperature, however, although lower, stimulatory response to cold for 2 hrs was also observed. In separate examinations, Na+-K+ ATPase activity in the extract of skeletal muscle was determined and enhanced significantly after 1 hr and 2 hrs. The results appear to indicate that the increased Pi in response to cold might be due to the higher activity of Na+-K+ ATPase. To clarify the regulatory mechanism of the enzyme, groups of fish were exposed to cold with 100 mM Na2HAsO4 for 1 hr and 2 hrs. The enhanced Na+-K+ ATPase activity was reduced significantly when treated with Na2HAsO4 compared to the control and also to the respective cold exposed fish. The experimental findings indicate that arsenic is involved in the regulation of cold induced Na+-K+ ATPase activity. The enhanced Na+-K+ ATPase activity in skeletal muscle of this species in cold and its inhibition by arsenic may play a critical role in environment. Keywords : Skeletal muscle, arsenic, Na+-K+ ATPase, sympathetic innervations, cold exposure