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Turkish Journal of Fisheries and Aquatic Sciences 2023, Vol 23, Num, 7     (Pages: TRJFAS22862)
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Assessment of Biosafety and Fillet-residues After Florfenicol Exposures in Trachinotus blochii to Ensure Safe-applications in Disease Incidences

Krupesha Sharma S.R. 1 ,Sumithra T.G. 1 ,Rameshkumar P. 2 ,Anikuttan K. 2 ,Ambarish P. Gop 3 ,Ratheesh Kumar R. 4 ,Aswathy Joshy 1 ,Vishnu Prasad 1 ,Suja G. 1 ,Rajisha R. 5 ,Panda S.K. 5 ,Tamilmani G. 2 ,Anil M.K. 3 ,Prasanna Kumar Patil 6

1 Marine Biotechnology, Fish Nutrition and Health Division, ICAR-CMFRI, Ernakulam North PO, Kochi 682018, Kerala, India
2 Mandapam Regional Centre of ICAR-CMFRI, Marine Fisheries P.O., Mandapam, Tamil Nadu, India, PIN: 623520
3 Vizhinjam Regional Centre of ICAR-CMFRI, Vizhinjam P.O., Thiruvananthapuram, Kerala, India, PIN: 692521
4 Marine Biodiversity and Environment Management Division, ICAR-CMFRI, Ernakulum North PO, Kochi, Kerala, India PIN: 682018
5 Quality Assurance and Management Division, ICAR-Central Institute of Fisheries Technology, Matsyapuri P.O., Kochi, Kerala, India, PIN: 682029
6 Aquatic Animal Health and Environment Division, ICAR-Central Institute of Brackishwater Aquaculture, Santhome High Road, Chennai, Tamil Nadu, India, PIN: 600028 DOI : 10.4194/TRJFAS22862 Viewed : 961 - Downloaded : 940 Trachinotus blochii is a promising mariculture fish species. Scientific data on biosafety and fillet residues of florfenicol exposure, one recommended amphenicol antimicrobial for aquaculture use, remains unknown in T. blochii, despite its criticality for prudent application. Accordingly, the paper evaluated the safety (regarding mortality, symptoms, weight gain, and histopathology) of dietary florfenicol after therapeutic (10 mg Kg-1 for ten days) and excessive (three, five, and ten times the therapeutic dose for 10, 20, and 30 days) exposures. There was no mortality in any group. The clinical abnormalities were noted only in 10X group from the 25th exposure day, which disappeared on the fourth day after withdrawal. Reduced growth was recorded at 5X and 10X groups from 20 and 30 exposure days, respectively. Histological lesion`s severity was in the liver > kidney > gill > spleen > muscle > intestine. The lesion severity relied on the quantity and duration of exposures, with maximum severity in 5X and 10X groups on the 30th day. After recommended therapeutic exposure, fillet residues were below the maximum residual limit accepted by the European Union (1000 μg Kg-1) from day three of the withdrawal, showing a minimum three-day is necessary to reach a safe, acceptable level. Keywords : Silver pompano Florfenicol amine Histopathology Withdrawal period Antibiotics